Corticosteroïds (systemic route)

The systemic exposure to pegaptanib is expected to be very low after ocular administration.

There are no animal studies.

After oral administration, the systemic exposure is proportional to dose up to 500 mg.

Concomitant systemic use of itraconazole or ketoconazole and INTELENCE may increase plasma concentrations of etravirine.

The systemic exposure to the dams associated with this finding was similar to exposure in humans, following administration of the recommended dose.

Systemic toxicity due to intravenous administration of cytarabine consists primarily of bone marrow suppression with leucopenia, thrombocytopenia and anaemia.

Allopurinol, procainamide, cytostatics or immunosuppressive agents (systemic corticosteroids) may lead to an increased risk of leukopenia when administered concomitantly with ACE inhibitors.

Distribution Following intravenous administration, the mean volume of distribution was 76 26 l, and systemic clearance was 147 47 l h.

No systemic accumulation was observed when ibandronic acid was administered intravenously once every 4 weeks for 48 weeks to patients with metastatic bone disease.

Elimination Median systemic clearance (CL) following a single intravenous administration to patients with psoriasis ranged from 1.99 to 2.34 ml day kg.

Data on other CYP3A4 inducers, e. g. carbamazepine, phenobarbital, phenytoin and St John's wort are lacking, but their concomitant administration is expected to lead to reduced systemic exposure to bosentan.

Data on other CYP3 A4 inducers, e.g. carbamazepine, phenobarbital, phenytoin and St John's wort are lacking, but their concomitant administration is expected to lead to reduced systemic exposure to bosentan.

Systemic undesirable effects

Systemic pharmacokinetics

Systemic toxicity

Systemic side effects

Dysgeusia (bitter or unusual taste in the mouth following instillation) was the most frequently reported systemic undesirable effect associated with the use of AZOPT during clinical studies.

C. Systemic issues

Antibacterial for systemic use JO1

Ongoing systemic infection.

Prolonged systemic exposure to intense immunosuppression in transplant patients following systemic administration of calcineurin inhibitors has been associated with an increased risk of developing lymphomas and skin malignancies.

Taking Systemic Risk Seriously

Uncommon reported side effects (experienced in more than 1 in 1,000 but less than 1 in 100 patients) Systemic allergic reactions Generalised allergy to insulin.

113 Uncommon reported side effects (experienced in more than 1 in 1,000 but less than 1 in 100 patients) Systemic allergic reactions Generalised allergy to insulin.

contraindicated to, or intolerant to two or more systemic therapies

Can We Regulate Systemic Risk?

uncommon mitral regurgitation, pulmonary embolism, other systemic embolism cerebral

Systemic clearance is independent of dose.

Systemic corticosteroids reduce calcium absorption.

4.6 Use during pregnancy and lactation

These include diuretics and laxatives supraphysiological use of steroid hormones with mineralocorticoid potential (e. g. systemic fludrocortisone)

Effect of food on absorption The systemic exposure (AUC) to etravirine was decreased by about 50 when INTELENCE was administered under fasting conditions, as compared to administration following a meal.

This section is divided into the following sub sections

Introduction b.

INSTRUCTIONS FOR PREPARING AND GIVING AN INJECTION OF ENBREL

Administration

Administration

35 Administration

Shake well before use

Not applicable

mg emodepside

Pharmaceutical

Corrects systemic control deficiencies in high risk areas

Antibacterials for systemic use.