Sunitinib was not mutagenic in bacteria using metabolic activation provided by rat liver.

Oral contraceptives bexarotene can potentially induce metabolic enzymes and thereby theoretically reduce the efficacy of oestroprogestive contraceptives.

Patients with chronic renal failure are predisposed to developing metabolic acidosis.

A synergistic and bactericidal effect occurs when trimethoprim is combined with sulfamethoxazole, because trimethoprim and sulfamethoxazole inhibit sequential steps in the synthesis of tetrahydrofolic acid, an essential metabolic cofactor in bacterial synthesis of purine and, subsequently, DNA.

Thus, if treatment with bexarotene is intended in a woman with childbearing potential, a reliable, non hormonal contraceptive method is also recommended.

In both studies, higher renal elimination was observed in the hepatically impaired patients.

Treatment with nucleoside analogues should be discontinued when rapidly elevating aminotransferase levels, progressive hepatomegaly or metabolic lactic acidosis of unknown aetiology occur.

Treatment with nucleoside analogues should be discontinued if there is symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

This regimen requires close monitoring (metabolic status, acid base and electrolyte status, vital parameters etc.) in an intensive care unit or similar setting.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

Mutagenicity in vitro and in vivo studies with and without metabolic activation have shown that nelfinavir has no mutagenic or genotoxic activity.

The likelihood of metabolic interactions is low due to limited metabolism and plasma protein binding and almost complete renal elimination of unchanged substance.

The likelihood of metabolic interactions is low due to limited metabolism and plasma protein binding and almost complete renal elimination of unchanged substance.

5 Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

It was found that concomitant treatment of losartan with rifampicine (inducer of matabolism enzymes) gave a 40 reduction in plasma concentration of the active metabolite.

Demand

Studies in patients aged 13 17 years showed various adverse reactions, including weight gain, changes in metabolic parameters and increases in prolactin levels.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

Need it? I don't need anything. I'm rich needing is for poor people. Only poor people need things.

Breast feeding It is not known whether betaine is excreted in human milk (although its metabolic precursor, choline, occurs at high levels in human milk).

Treatment with NRTIs should be discontinued if there is symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

On Demand

No need.

Extra require ments

The differentiated appropriations would be automatically carried over.

No demand!

These findings occurred at doses that caused metabolic acidosis with decreased body weight gain in dams and decreased foetal weights.

Rotigotine did not induce gene mutations in the Ames test, but did show effects in the in vitro Mouse Lymphoma Assay with metabolic activation and weaker effects without metabolic activation.

Atorvastatin did not demonstrate mutagenic or clastogenic potential in 4 in vitro tests with and without metabolic activation and in 1 in vivo assay.

Need Versus Greed

Load on demand

Prompt as needed

Update on demand

2002

The task of the economy is to satisfy demand.

It's risk and demand.

Treatment with nucleoside analogues must be discontinued in the setting of symptomatic hyperlactataemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactataemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactatemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

These tasks should respond to the needs of the European institutions, the social partners at all levels, the national and regional institutions and business.

Treatment with nucleoside analogues should be discontinued in the setting of symptomatic hyperlactataemia and metabolic lactic acidosis, progressive hepatomegaly, or rapidly elevating aminotransferase levels.

The breath test concept relies on the administration of a specifically 13C labelled urea whose metabolite utilisation is monitored by measuring 13CO2 in the expired breath gas.

The breath test concept is based upon the oral administration of 13C labelled urea whose enzymatic hydrolysis is monitored by measuring 13CO2 in breath using non dispersive infrared spectrometry.

Due to limited experience in patients with decreased metabolic capacity of the liver, Ketek should be used with caution in patients with hepatic impairment (see also section 4.4).