Adverse Reaction

Adverse reaction

Adverse Drug Reaction

Adverse Reactions

Treatment Related Adverse Reactions reported in GIST studies

7 (1.3 )

36 (6.6 ) 25 (4.6 )

Adverse reactions

Adverse event

Adverse drug reactions

Adverse Reaction Event

Reactions (frequency )

Spleen disorder

System Organ Class Adverse reaction Gastrointestinal system

Adverse Reaction System Organ Class

Nervous system disorders

This side effect is a

Undesirable effect Spleen disorder

Common

Common

System Organ Class Adverse reaction Gastrointestinal system

6 Adverse Reaction System Organ Class

General Disorders and Administration Injection site hypertrophy Site Conditions

Adverse reaction All grades

Adverse reaction event

Reproductive system and breast disorders

MedDRA Preferred Term

Body System Frequency of Reaction

Adverse Drug Reaction

Hypertension Thromboembolic event

Adverse reaction Grade 2 4

Body system Adverse event

Body system Adverse event

Undesirable effect Anaemia, splenomegaly Thrombocytopenia Spleen disorder

Class Adverse reaction Frequency Number ( ) (n 352)

Undesirable effect Very common ( 1 10)

dizziness, headache, paraesthesia diarrhoea, dyspepsia, nausea, vomiting erythema, pruritus, rash, urticaria

The most likely side effect is bleeding.

A painkiller that's virtually side effect free

Undesirable effect Allergic reactions (see section 4.4)

The most common adverse drug reaction is diarrhoea.

He did not experience an adverse reaction as a result.

Hypertensive encephalopathy

Diabetes has been observed as a rare side effect.

This is a common side effect.