Lenalidomide has a potential for acute toxicity minimum lethal doses after oral administration were 2000 mg kg day in rodents.

Irbesartan hydrochlorothiazide the potential toxicity of the irbesartan hydrochlorothiazide combination after oral administration was evaluated in rats and macaques in studies lasting up to 6 months.

All Grades Grade 3 Toxicity 4 Toxicity ( ) ( )

Toxicity Haematological toxicity during a cycle

Table3 Posology modifications during subsequent cycles Toxicity Haematological toxicity during a cycle

Grade All

Grade

Grades 3 4 Grades

Toxicity

Dose per

Dose changes within a treatment cycle

Area (m)

Are they a potential mate?

The potential risk for humans is unknown.

Reactivity 10.2.

Chronic Toxicity

Cardiac toxicity

Dermal toxicity

Acute toxicity

Haematological Toxicity Grade

Haematologic toxicity

Mitochondrial toxicity

Systemic toxicity

97 Haematologic toxicity

111 Haematologic toxicity

139 Haematologic toxicity

Trimetrexate toxicity Prevention

Aquatic toxicity

Toxicity 10000

Toxicity 5000

Toxicity 1000

Toxicity 100

Toxicity 50

Toxicity 10

Those children are potential customers.

This is a potential threat.

So now I have potential energy.

Scientific advice to future applicants

So much for subparagraphs (a) and (b) of my amend ment.

Blood and Lymphatic System

Local toxicity

Hepatic and renal toxicity WHO Grade 3 or 4 hepatic toxicity was observed in 12 of patients following administration of Herceptin as single agent, in the metastatic setting.

TMZ discontinuation

(severe) mucosal toxicity.

Toxicity for the combination