Predictor

Determination of Response

Loss of response to romiplostim

Cross Study Comparison of ACR Responses at Week 24 (ITT Population)

Cross Study Comparison of

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The median duration of response was 12 weeks.

And if I've got a good predictor, it predicts the same thing.

D percent of full scale analyser response due to A.

Maintenance of Clinical Remission and Response (Percent of Patients) no

Table 11 Induction of Clinical Remission and Response (Percent of Patients) Week 4

23 Table 12 Maintenance of Clinical Remission and Response (Percent of Patients)

Median time to loss of response through week 54 Week 30

Median time to loss of response through week 54 Week 54

Maintenance of remission and response rates are presented in Table 12.

50 Table 12 Maintenance of Clinical Remission and Response (Percent of Patients)

77 Table 12 Maintenance of Clinical Remission and Response (Percent of Patients)

104 Table 12 Maintenance of Clinical Remission and Response (Percent of Patients)

Imputations according to the TLOVR algorithm (TLOVR Time to Loss of Virologic Response)

The overall sustained response rate after a 24 week treatment duration was 50 .

sustained response by viral response at week 12 and genotype

Predictability of sustained response by viral response at week 12 and genotype

The durability of the response was similar to that seen in adult patients.

Induction of Clinical Remission and Response (Percent of Patients)

Maintenance of remission and response rates are presented in Table 10.

Induction of Clinical Remission and Response (Percent of Patients)

Induction of Clinical Remission and Response (Percent of Patients)

Induction of Clinical Remission and Response (Percent of Patients)

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A loss of response or failure to maintain a platelet response with romiplostim within the recommended dosing range should prompt a search for causative factors (see section 4.4, loss of response to romiplostim).

Duration of response (in both classifications of response (n 5) ranged between 15 and 195 weeks.

The combination of trazodone with indinavir ritonavir should be used with caution, initiating trazodone at the lowest dosage and monitoring for clinical response and tolerability.

However, in several studies, the objective criteria for evaluating tumour response are missing or not reported.

The median time to onset of response in the infliximab treated group was 2 weeks.

The absorption of nelfinavir may be reduced in situations where the gastric pH is increased irrespective of cause.

Serum ferritin assessed by monthly monitoring reflected changes in liver iron concentration indicating that trends in serum ferritin can be used to monitor response to therapy.

This dose should be gradually increased according to individual patient requirements based on the clinical response and serum IGF 1 concentrations.

Of the patients who lost adequate response after re randomization to placebo who then enrolled into the open label extension trial, 38 (25 66) and 55 (36 66) regained PASI 75 response after 12 and 24 weeks of re treatment, respectively.

In Psoriasis Study I, 28 of patients who were PASI 75 responders and were re randomised to placebo at Week 33 compared to 5 continuing on Humira, p 0.001, experienced loss of adequate response (PASI score after Week 33 and on or before Week 52 that resulted in a PASI 50 response relative to baseline with a minimum of a 6 point increase in PASI score relative to week 33).

The combination of INTELENCE and atorvastatin can be given without any dose adjustments, however, the dose of atorvastatin may need to be altered based on clinical response.

Predictive Value of Week 12 Virological Response at the Recommended Dosing Regimen while on Pegasys Combination Therapy Genotype

At week 4, following administration of a single dose, 22 27 (81 ) of infliximab treated patients receiving a 5 mg kg dose achieved a clinical response vs.

Predictability of sustained virological response in naïve patients Virological response by week 12, defined as a 2 log viral load decrease or undetectable levels of HCV RNA has been shown to be predictive for sustained response (Table 8).

After consolidation of the antidepressive response, it is recommended to continue treatment for several months, in order to avoid relapse.

2 After consolidation of the response, it is recommended to continue treatment for several months, in order to avoid relapse.