Motor neuropathy

1.7 )

0.4 ) neuropathy (G3 4

Peripheral motor neuropathy (G3 4

0 ) Peripheral sensory Neurocortical (G3 4 neuropathy (G3 4

4.1 ) Peripheral motor neuropathy (G3 4

3.7 ) Peripheral motor neuropathy (G3 4

2.3 ) Peripheral motor neuropathy (G3 4

2.0 ) Peripheral motor neuropathy (G3 4

GGT increase, chest pain, arrhythmia, and motor neuropathy.

Peripheral motor 0.7 ) neuropathy (G3 4

Rare motor neuropathy (with resultant minor distal weakness)

Peripheral sensory neuropathy, headache, dysgeusia, dizziness, peripheral motor neuropathy, ataxia, sensory disturbance, somnolence.

Grade 4 (sensory neuropathy which is disabling or motor neuropathy that is life threatening or leads to paralysis) and or severe autonomic neuropathy

9 Clinically relevant CTC toxicities that were reported in 1 and 5 (common) of the patients that were randomly assigned to pemetrexed include infection without neutropenia, febrile neutropenia, allergic reaction hypersensitivity, increased creatinine, motor neuropathy, sensory neuropathy, erythema multiforme, and abdominal pain.

26 Clinically relevant CTC toxicities that were reported in 1 and 5 (common) of the patients that were randomly assigned to pemetrexed include infection without neutropenia, febrile neutropenia, allergic reaction hypersensitivity, increased creatinine, motor neuropathy, sensory neuropathy, erythema multiforme, and abdominal pain.

Clinically relevant CTC toxicities that were reported in 1 (uncommon) of the patients that were randomly assigned to receive cisplatin and pemetrexed include arrhythmia and motor neuropathy.

Motor Impairments

Neuralgia, peripheral neuropathy, neuropathy

Peripheral neuropathy, neuropathy, hypoaesthesia, paraesthesia.

Neuropathy

Cardiac disorders

peripheral neuropathy, peripheral sensory neuropathy (see section 4.4),

Parkinson s disease and are also taking levodopa, you might develop dyskinesia during the uptitration of Oprymea.

a) Motor and sensorimotor sequelae

hyperglycaemia, weight decrease, peripheral oedema, face

hyperglycaemia, weight decrease, peripheral oedema, face oedema, increased LDH, hypocalcaemia

Neuropathy sensory

peripheral neuropathy

Peripheral neuropathy

Peripheral neuropathy

Painful neuropathy.

Peripheral neuropathy

Very common headache Common neuropathy (including

0 (0 ) 0 (0 ) 0 (0 ) 0 (0 )

Autonomic neuropathy

Uncommon peripheral neuropathy.

Sensory neuropathy

Cerebrovascular accident, syncope, peripheral neuropathy, neuropathy, peripheral sensory neuropathy, dizziness, ageusia, dysgeusia, paraesthesia, headache, tremor , hypoaesthesia , somnolence, memory impairment

Neuropathy, primarily peripheral sensory neuropathy, occurs very commonly and is usually of mild to moderate intensity.

Motor Impairments and Mouseless Operation

Hypertensive crisis with encephalopathy like symptoms (e. g. headaches and confused state, sensorimotor disorders such as speech disturbance or impaired gait up to tonoclonic seizures) may also occur in individual patients with otherwise normal or low blood pressure (see section 4.4).

Neuropathy Sensory

depression

Painful neuropathy.