A non dose related low incidence of cardiovascular malformations was observed in etoricoxib treated rabbits.

Data on the development of anti panitumumab antibodies has been evaluated using two different immunoassays (an ELISA which detects high affinity antibodies, and a Biosensor Immunoassay which detects both high and low affinity antibodies), results from these assays indicated that the overall incidence of a post dose anti panitumumab antibody response was low.

event rate ( )

rate (CI)

event rate event rate ( ) ( )

Incidence ( )

Endpoint Incidence of Zoster Incidence of PHN HZ Pain BOI

Incidence of Zoster

fracture incidence (CI)

The incidence of heart failure on triple oral therapy was 1.4 in the main double blind study, compared to 0.4 for metformin plus sulphonylurea dual therapy.

Incidence of

FORSTEO may cause small increases in urinary calcium excretion, but the incidence of hypercalciuria did not differ from that in the placebo treated patients in clinical trials.

Enviage has been evaluated for safety in more than 7,800 patients, including over 2,300 treated for over 6 months, and more than 1,200 for over 1 year.

Incidences ( ) Risk ratio over

N Incidences ( ) Risk ratio over

Riprazo has been evaluated for safety in more than 7,800 patients, including over 2,300 treated for over 6 months, and more than 1,200 for over 1 year.

Sprimeo has been evaluated for safety in more than 7,800 patients, including over 2,300 treated for over 6 months, and more than 1,200 for over 1 year.

Tekturna has been evaluated for safety in more than 7,800 patients, including over 2,300 treated for over 6 months, and more than 1,200 for over 1 year.

Incidence of clinical vertebral fracture

ibandronic acid 2.5 mg daily

Incidences ( ) Risk ratio over enoxaparin

In course 1 the incidence was 20 , by courses 4 the incidence was 8 .

the low population density

Low Volume

Marginally trusted

(low power)

Low population density

(a) Incidence (number of new cases)

Incidence of new morphometric vertebral fractures

Secondary Efficacy (platelet reduction, incidence of thrombohaemorrhagic events).

The higher incidence of death was not associated with olanzapine dose (mean daily dose 4.4 mg) or duration of treatment.

In patients with haemophilia type A and B, there have been reports of increased bleeding while taking this treatment or another protease inhibitor.

Appropriate precautions (e.g. use of a condom) should be taken to prevent passing on the disease through sexual contact.

reduction in incidence (CI)

Incidence of clinical vertebral fracture

Fracture Incidence in Postmenopausal Women

Incidence of hypoglycaemia at endpoint Bodyweight gain2

Incidence of hypoglycaemia at endpoint Bodyweight gain2 1 from baseline to end of Liprolog Mix25 treatment 2

Separate analysis of the individual end points show little differences in incidence between the groups treated with nifedipine or diuretics of stroke (2.0 versus 2.3 ), MI (2.9 versus 2.7 ) and death caused by any other cardiovascular disease (0.4 versus 0.4 ).

Low Activity

4.1.2 Poorly regarded

4.1.3 Low educational attainment

A long term oral carcinogenicity study in mice showed a low incidence of duodenal tumours, considered likely related to high local concentrations in the gastrointestinal tract at a dose of 600 mg kg day.

A long term oral carcinogenicity study in mice showed a low incidence of duodenal tumours, considered likely related to high local concentrations of tenofovir disoproxil fumarate in the gastrointestinal tract at a dose of 600 mg kg day.

A long term oral carcinogenicity study in mice showed a low incidence of duodenal tumours, considered likely related to high local concentrations in the gastrointestinal tract at a dose of 600 mg kg day.