Co administration of sirolimus (2 mg single dose) with multiple dose administration of oral voriconazole (400 mg every 12 hours for 1 day, then 100 mg every 12 hours for 8 days) in healthy subjects has been reported to increase sirolimus Cmax and AUC by an average of 7 fold and 11 fold respectively.

And then in the situation when we're switching, if over here let's look at this situation. We're concave downwards.

Instances of abnormal hepatic function with elevated hepatic enzymes accompanied by elevated bilirubin have been reported.

And maidens incomparable.

And raised couches.

and upraised couches.

And carpets raised.

And on couches or thrones, raised high.

And uplifted mattresses.

They shall be on upraised couches,

And raised couches

and noble spouses.

And couches raised up.

And upon beds raised high.

undiminished and never denied

And exalted thrones.

on raised couches.

And on Thrones (of Dignity), raised high.

And maidens incomparable.

Exalted and holy,

And raised couches.

Exalted, pure.

and upraised couches.

uplifted, purified,

And carpets raised.

Exalted, Purified,

And on couches or thrones, raised high.

Exalted (in dignity), purified,

And uplifted mattresses.

Exalted and purified.

They shall be on upraised couches,

most exalted and purified,

And raised couches

Exalted, purified,

and noble spouses.

exalted and purified,

And couches raised up.

exalted, purified,

And upon beds raised high.

Exalted and purified,

undiminished and never denied

And exalted thrones.

on raised couches.

And on Thrones (of Dignity), raised high.

Exalted (in dignity), kept pure and holy,