atrophic endometrium.

peripheral nervous system disorders association of sensory disorders, muscular weakness and

degradation of the mucous membrane of the uterus (atrophic endometrium)

degradation of the mucous membrane of the uterus (atrophic endometrium)

Effects on vulvar and vaginal atrophy (VVA)

Retinal haemorrhage, optic atrophy, oculogyration, corneal opacity

In dogs, renal tubular dilation and atrophy were observed.

Those occurring at the injection site injection site atrophy, injection site haemorrhage, injection site mass and hypertrophy.

Uncommon exanthem, lipoatrophy, lipodystrophy acquired, lipohypertrophy.

In dogs renal tubular dilation and atrophy were observed.

Muscular atrophy (reduction of muscular tissue) of the ball of the thumb and sensory

Retinal disorder (such as peripheral retinal atrophy)

Gastrointestinal colitis including cytomegalovirus colitis, (common), pancreatitis, (common) and intestinal villous atrophy.

Chronic dosing effects observed in at least one animal species or study included effects on the cornea (atrophy, ulceration), skin (follicular degeneration and inflammation, redness, and alopecia), ovary (atrophy), liver (liver necrosis), kidney (renal papillary necrosis and tubular dilatation), and gastrointestinal tract (delayed gastric emptying and diarrhoea).

Pollakiuria, micturition urgency, renal impairment Erectile dysfunction , testicular atrophy , gynaecomastia , pelvic pain, prostatitis, prostate tenderness, retrograde ejaculation, testicular pain

peripheral oedema Common injection site reactions, asthenia Uncommon injection site atrophy, injection site haemorrhage, injection site mass, hypertrophy

See also Olivopontocerebellar atrophy Optic atrophy Spinomuscular atrophy Hypertrophy References

Tacrolimus ointment did not reduce skin thickness and did not cause skin atrophy in animals.

Reductions in testicular weights and or histological lesions (e. g. tubular atrophy and tubular giant cells) were observed in rats and in a monkey study.

Administration of pemetrexed to male mice resulted in reproductive toxicity characterised by reduced fertility rates and testicular atrophy.

Tacrolimus ointment did not reduce skin thickness and did not cause skin atrophy in animals.

The muscle mass and the degree of hypertrophy or atrophy are factors to be taken into consideration when selecting the appropriate dose.

These studies are used to define the dosage to be used in human testing (phase I), as well as to calculate the maximum admissible daily intake.

Caelyx resulted in mild to moderate ovarian and testicular atrophy in mice after a single dose of 36 mg kg.

Also, in rats testicular atrophy with decreased spermatogenesis occurred, while in dogs reversible spermatogenic arrest was noted.

Gastrointestinal colitis including cytomegalovirus colitis, ( 1 100 to 1 10), pancreatitis, ( 1 100 to 1 10) and intestinal villous atrophy.

Gastrointestinal colitis including cytomegalovirus colitis, ( 1 100 to 1 10), pancreatitis ( 1 100 to 1 10) and intestinal villous atrophy.

32 Gastrointestinal colitis including cytomegaloviruscolitis, ( 1 100 to 1 10), pancreatitis ( 1 100 to 1 10) and intestinal villous atrophy.

Reductions in testicular weights and or histological lesions (e. g., tubular atrophy and tubular giant cells) were observed in mice, rats, and monkeys.

Cases of interstitial nephritis with medullary calcification and cortical atrophy have been observed in patients with asymptomatic severe leucocyturia ( 100 cells high power field).

That chronic administration of Volibris in animals has been linked to testicular tubular atrophy and impaired fertility.

That chronic administration of Volibris in animals has been linked to testicular tubular atrophy and impaired fertility.

acne, dermatitis acneiforme, dry skin, erythema, facial wasting, lipoatrophy, lipodystrophy acquired, lipohypertrophy, prurigo, pruritis generalised, rash macular, rash maculo papular, rash pruritic, xeroderma

However, neovascular AMD that has evolved into lesions characterised by subretinal fibrosis and

The development of testicular tubular atrophy in male animals has been linked to the chronic administration of ERAs, including ambrisentan (see section 5.3).

Pathologists should be made aware of a history of lasofoxifene use when assessing endometrial histology, to ensure an accurate diagnosis of benign cystic atrophy when present.

Testicular tubular atrophy, which was occasionally associated with aspermia, was observed in oral repeat dose toxicity and fertility studies with male rats and mice without safety margin.

Atrophy of the thymus, lymphoid tissues, and testis, and hypertrophy of the adrenals, were reported at doses of 100 mg kg day or greater in non iron loaded animals.

Adverse reactions not observed in clinical studies, but seen in animals at exposure levels similar to or even lower than clinical exposure levels and with possible relevance to clinical use, were as follows pancreatic islet cell vacuolation (rat), testicular tubular degeneration (mouse, rat and monkey), lymphoid atrophy (mouse, rat and monkey), mixed cell inflammation of the colon caecum (monkey), and pulmonary phospholipidosis (rat).

In the 26 week study, moderate to marked diffuse seminiferous tubular atrophy was present at a very low incidence, whereas in the 99 week study there was a dose related, slightly increased incidence of minimal to mild focal atrophy at doses providing 29 to 94 times the human exposure.

These included, in some subjects, a small excess in the incidence of vaginal bleeding as well as endometrial cystic change viewed on ultrasound and histological benign cystic atrophy (a variant of atrophic endometrium).

Medics know how so called irrevocable processes take place, how body's organs begin to atrophy, what horrible failures happen in one's organism, hormones, blood, stomach, liver, spleen, bones...

In juvenile dogs, 39 weeks treatment did not induce lesions in the testis and epididymides in a dose dependent manner at the end of treatment but after a treatment free period of 13 weeks a dose dependent increase in these lesions were noted in the treated recovery groups.

In repeated dose toxicity studies in rats and dogs, lymphoid depletion atrophy of lymph nodes, spleen and thymus, decreased erythrocytes, reticulocytes, leukocytes, and platelets, in association with bone marrow hypocellularity, and adverse renal and gastrointestinal effects have been seen with tigecycline at exposures of 8 and 10 times the human daily dose based on AUC in rats and dogs, respectively.

Xeomin should be used with caution if bleeding disorders of any type occur in patients receiving anticoagulant therapy in patients suffering from amyotrophic lateral sclerosis or other diseases which result in peripheral neuromuscular dysfunction in targeted muscles which display pronounced weakness or atrophy.